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Although it has been recommended that N-acetyl-5-aminosalicylic acid may be pharmacologically energetic, therapeutic response has been poor in some patients handled rectally with this metabolite, and the relative contribution of this metabolite to the therapeutic impact of mesalamine remains questionable.N-acetyl-5-aminosalicylic acid did not inhibit lipoxygenase in vitro.
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Although the potential for adversarial mesalamine-induced renal results seems to be low following rectal administration, the potential of such effects occurring in sufferers receiving the drug needs to be thought-about, significantly when elevated GI absorption or decreased renal elimination of the drug is feasible or when a nonsteroidal anti-inflammatory agent or an oral preparation containing or metabolized to mesalamine is administered concomitantly.
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