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Results: The endoscopic remission induction fee from the attending physicians' evaluations was eighty two.8% in the mesalazine suppository group and 31.1% in the placebo suppository group, whereas the respective charges from the central review committee were 90.6% and 59.zero%. Nevertheless, there was a distinction of 27.9 proportion factors between the remission induction rates of the placebo group found by the 2 groups of raters.
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SalofalkŪ (Dr Falk GmBH, Freiburg, Germany), MesasalŪ (Aspen Pharmacare, NSW, Australia) and ClaversalŪ (Merckle GmbH, Ulm, Germany), comprise mesalazine enclosed inside an Eudragit-L coating which disintegrates at pH ≥ 6, thus preferentially releasing the drug throughout mid to distal ileum and colon 20 A potential subject with this mode of delivery is that colonic pH, though highly variable, is total decreased in sufferers with inflammatory bowel illness 21 It has been postulated that the lowered colonic pH could impede the release of 5-ASA from the pH dependent enteric coating and reduce its efficacy.